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Differentiation syndrome in acute myeloid leukemia after treatment with azacitidine
We report a case report of hyperleukocytosis, fever, hypotension, pulmonary and pericardial effusions, and acute kidney injury during initial treatment with azacitidine in a patient with AML‐MRC. Collectively, the symptomatology resembled differentiation syndrome. Azacitidine has been previously ass...
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| Published in: | European journal of haematology 2015-11, Vol.95 (5), p.484-485 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c3258-3cfc46232967624b8e3aa1d0e6de32c53d1ddc4d116a50ba09d764c361db88d83 |
| container_end_page | 485 |
| container_issue | 5 |
| container_start_page | 484 |
| container_title | European journal of haematology |
| container_volume | 95 |
| creator | Laufer, Christin B. Roberts, Owen |
| description | We report a case report of hyperleukocytosis, fever, hypotension, pulmonary and pericardial effusions, and acute kidney injury during initial treatment with azacitidine in a patient with AML‐MRC. Collectively, the symptomatology resembled differentiation syndrome. Azacitidine has been previously associated with fever, peripheral edema, and hyperleukocytosis, but its side effect profile has never been described as similar to differentiation syndrome. The patient's deteriorating course quickly turned around after treatment with dexamethasone. This potential reaction, and potential treatment, is important for clinicians to be aware of. |
| doi_str_mv | 10.1111/ejh.12598 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0902-4441 |
| ispartof | European journal of haematology, 2015-11, Vol.95 (5), p.484-485 |
| issn | 0902-4441 1600-0609 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Aged Azacitidine Azacitidine - administration & dosage Azacitidine - adverse effects Differentiation syndrome Female Fever - chemically induced Fever - drug therapy Fever - pathology Fever - physiopathology Humans Hypotension - chemically induced Hypotension - drug therapy Hypotension - pathology Hypotension - physiopathology Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - physiopathology Pericardial Effusion - chemically induced Pericardial Effusion - drug therapy Pericardial Effusion - pathology Pericardial Effusion - physiopathology Syndrome |
| title | Differentiation syndrome in acute myeloid leukemia after treatment with azacitidine |
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