Survival and graft-versus-host disease in patients receiving peripheral stem cell compared to bone marrow transplantation from HLA-matched related donor: retrospective analysis of 334 consecutive patients

Objectives The objective of this study was to compare the major transplant outcomes between patients receiving hematopoietic stem cell transplantation (HSCT) from bone marrow (BM) or peripheral blood stem cells (PBSC). Methods All consecutive HSCT patients using BM or PBSC from an HLA‐matched relate...

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Published in:European journal of haematology 2015-11, Vol.95 (5), p.421-425
Main Authors: Campregher, Paulo Vidal, Hamerschlak, Nelson, Colturato, Vergilio Antonio Renzi, Mauad, Marcos Augusto, de Souza, Mair Pedro, Bouzas, Luis Fernando da Silva, Tavares, Rita de Cássia B., Barros, José Carlos, Chiattone, Ricardo, Paz, Alessandra, Silla, Lucia, Vigorito, Afonso Celso, Miranda, Eliane, Funke, Vaneuza Araújo Moreira, Flowers, Mary Evelyn
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Allografts
Bone Marrow Transplantation
Child
Child, Preschool
Disease-Free Survival
Female
Follow-Up Studies
Graft vs Host Disease - etiology
Graft vs Host Disease - mortality
haematological neoplasms
Hematologic Neoplasms - mortality
Hematologic Neoplasms - therapy
hematopoietic stem cell transplantation
Humans
Infant
Male
Middle Aged
multicenter study
Peripheral Blood Stem Cell Transplantation
Retrospective Studies
Survival Rate
Tissue Donors
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Summary:Objectives The objective of this study was to compare the major transplant outcomes between patients receiving hematopoietic stem cell transplantation (HSCT) from bone marrow (BM) or peripheral blood stem cells (PBSC). Methods All consecutive HSCT patients using BM or PBSC from an HLA‐matched related donors for haematological malignancies after high intensity conditioning at seven Brazilian transplant centres between January 2008 and December 2009 were retrospectively evaluated. Results In the study period, 334 patients were treated in the centres and included in the evaluation. The cumulative incidence of grades II–IV and III–IV acute graft‐versus‐host disease (GVHD) at one year was 36.7% and 9.7% for BM recipients and 34.4% and 15.1% for PBSC recipients, respectively (not statistically different). The cumulative incidence of chronic GVHD at three years was 53.7% and 79.8% (HR 1.93; 95% CI 1.38–2.69, P 
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.12508