Role of sebaceous glands in inflammatory dermatoses

Skin is an important interface between the host and its environment. Inflammatory dermatoses often have disrupted skin barrier function, rendering patients more susceptible to allergenic triggers leading to an exaggerated immune response. The skin surface lipid film, an important component of the sk...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2015-11, Vol.73 (5), p.856-863
Main Authors: Shi, Vivian Y., MD, Leo, Michael, BS, Hassoun, Lauren, BS, Chahal, Dev S., BS, Maibach, Howard I., MD, Sivamani, Raja K., MD, MS, CAT
Format: Article
Language:English
Subjects:
acne
Acne Vulgaris - drug therapy
Acne Vulgaris - etiology
atopic dermatitis
Dermatitis, Atopic - etiology
Dermatitis, Atopic - pathology
Dermatitis, Seborrheic - metabolism
Dermatitis, Seborrheic - microbiology
Dermatology
eczema
Humans
Lipids - analysis
psoriasis
Psoriasis - etiology
rosacea
Rosacea - etiology
Sebaceous Glands - pathology
Sebaceous Glands - secretion
sebocytes
seborrheic dermatitis
sebum
Sebum - chemistry
Sebum - metabolism
Skin Physiological Phenomena
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Summary:Skin is an important interface between the host and its environment. Inflammatory dermatoses often have disrupted skin barrier function, rendering patients more susceptible to allergenic triggers leading to an exaggerated immune response. The skin surface lipid film, an important component of the skin barrier, comprises a mixture of keratinocyte and sebaceous gland–derived lipids. Recent evidence demonstrated that defective keratinocyte lipid synthesis predisposes for the development of atopic dermatitis. However, the important role of sebaceous gland–derived lipids in skin inflammatory diseases may be underrecognized. This overview focuses on the importance of the contribution of sebaceous glands to barrier function. Sebaceous gland alteration may play a role in the pathogenesis of common skin diseases including acne vulgaris, atopic dermatitis, psoriasis, rosacea, and seborrheic dermatitis.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2015.08.015