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Effects of levobupivacaine on isolated rat tracheal smooth muscle
Levobupivacaine has been developed as a safer alternative to bupivacaine because of its reduced systemic toxicity. However, the effect of directly delivering levobupivacaine into tracheal smooth muscle has not been adequately explored. We performed this study to determine the in vitro effects of lev...
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| Published in: | Journal of anesthesia 2015-10, Vol.29 (5), p.809-812 |
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| cites | cdi_FETCH-LOGICAL-c401t-764ca83bc30d480a4ad6149ed32afc579da62483a79254b3fad8bf4767e476ac3 |
| container_end_page | 812 |
| container_issue | 5 |
| container_start_page | 809 |
| container_title | Journal of anesthesia |
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| creator | Chang, Hung-Chi Chen, Shin-Yan Huang, Yu-Feng Liu, Feng-Lin Cherng, Yih-Giun Wang, Hsing-Won |
| description | Levobupivacaine has been developed as a safer alternative to bupivacaine because of its reduced systemic toxicity. However, the effect of directly delivering levobupivacaine into tracheal smooth muscle has not been adequately explored. We performed this study to determine the in vitro effects of levobupivacaine on isolated rat tracheal smooth muscle. A portion of rat trachea 5 mm in length was mounted in 30 ml of Krebs solution in a muscle bath at 37 °C. The following effects of levobupivacaine were assessed: (1) the effect on tracheal smooth muscle resting tension (
n
= 6), (2) the effect on contraction caused by 10
−6
M methacholine (
n
= 6) and (3) the effect on electrically induced tracheal smooth muscle contractions (
n
= 6). Levobupivacaine caused dose-dependent relaxation in the trachealis muscle precontracted with 10
−6
M methacholine. Contraction inhibition was statistically significant when 10
−5
and 10
−4
M levobupivacaine were applied, compared with the contraction inhibition that occurred in the control groups (
p
|
| doi_str_mv | 10.1007/s00540-015-2026-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1722931988</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1722931988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c401t-764ca83bc30d480a4ad6149ed32afc579da62483a79254b3fad8bf4767e476ac3</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwA1hQRpbA-SOOPVZV-ZAqscBsXRyHpkriYieV-PekSmFkuRvueV_pHkJuKTxQgPwxAmQCUqBZyoDJVJ2RORVcpYpn-pzMQVOeKinVjFzFuAMASSm_JDOWaZ2BhDlZrqvK2T4mvkoad_DFsK8PaLHuXOK7pI6-wd6VScA-6QParcMmia33_TZph2gbd00uKmyiuzntBfl4Wr-vXtLN2_PrarlJrQDap7kUFhUvLIdSKECBpaRCu5IzrGyW6xIlE4pjrlkmCl5hqYpK5DJ340DLF-R-6t0H_zW42Ju2jtY1DXbOD9HQnDHNqVZqROmE2uBjDK4y-1C3GL4NBXM0ZyZzZjRnjubMMXN3qh-K1pV_iV9VI8AmII6n7tMFs_ND6MaX_2n9AY4leLI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1722931988</pqid></control><display><type>article</type><title>Effects of levobupivacaine on isolated rat tracheal smooth muscle</title><source>Springer Link</source><creator>Chang, Hung-Chi ; Chen, Shin-Yan ; Huang, Yu-Feng ; Liu, Feng-Lin ; Cherng, Yih-Giun ; Wang, Hsing-Won</creator><creatorcontrib>Chang, Hung-Chi ; Chen, Shin-Yan ; Huang, Yu-Feng ; Liu, Feng-Lin ; Cherng, Yih-Giun ; Wang, Hsing-Won</creatorcontrib><description>Levobupivacaine has been developed as a safer alternative to bupivacaine because of its reduced systemic toxicity. However, the effect of directly delivering levobupivacaine into tracheal smooth muscle has not been adequately explored. We performed this study to determine the in vitro effects of levobupivacaine on isolated rat tracheal smooth muscle. A portion of rat trachea 5 mm in length was mounted in 30 ml of Krebs solution in a muscle bath at 37 °C. The following effects of levobupivacaine were assessed: (1) the effect on tracheal smooth muscle resting tension (
n
= 6), (2) the effect on contraction caused by 10
−6
M methacholine (
n
= 6) and (3) the effect on electrically induced tracheal smooth muscle contractions (
n
= 6). Levobupivacaine caused dose-dependent relaxation in the trachealis muscle precontracted with 10
−6
M methacholine. Contraction inhibition was statistically significant when 10
−5
and 10
−4
M levobupivacaine were applied, compared with the contraction inhibition that occurred in the control groups (
p
< 0.01). A high dose of levobupivacaine also decreased the spike contraction induced by electrical field stimulation. This study indicated that high concentrations of levobupivacaine might antagonize the cholinergic receptors and inhibit parasympathetic function of the trachea.</description><identifier>ISSN: 0913-8668</identifier><identifier>EISSN: 1438-8359</identifier><identifier>DOI: 10.1007/s00540-015-2026-8</identifier><identifier>PMID: 25995060</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Anesthesiology ; Animals ; Bupivacaine - analogs & derivatives ; Bupivacaine - pharmacology ; Critical Care Medicine ; Electric Stimulation ; Emergency Medicine ; Intensive ; Medicine ; Medicine & Public Health ; Methacholine Chloride - pharmacology ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Pain Medicine ; Rats ; Short Communication ; Trachea - drug effects ; Trachea - metabolism</subject><ispartof>Journal of anesthesia, 2015-10, Vol.29 (5), p.809-812</ispartof><rights>Japanese Society of Anesthesiologists 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-764ca83bc30d480a4ad6149ed32afc579da62483a79254b3fad8bf4767e476ac3</citedby><cites>FETCH-LOGICAL-c401t-764ca83bc30d480a4ad6149ed32afc579da62483a79254b3fad8bf4767e476ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25995060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Hung-Chi</creatorcontrib><creatorcontrib>Chen, Shin-Yan</creatorcontrib><creatorcontrib>Huang, Yu-Feng</creatorcontrib><creatorcontrib>Liu, Feng-Lin</creatorcontrib><creatorcontrib>Cherng, Yih-Giun</creatorcontrib><creatorcontrib>Wang, Hsing-Won</creatorcontrib><title>Effects of levobupivacaine on isolated rat tracheal smooth muscle</title><title>Journal of anesthesia</title><addtitle>J Anesth</addtitle><addtitle>J Anesth</addtitle><description>Levobupivacaine has been developed as a safer alternative to bupivacaine because of its reduced systemic toxicity. However, the effect of directly delivering levobupivacaine into tracheal smooth muscle has not been adequately explored. We performed this study to determine the in vitro effects of levobupivacaine on isolated rat tracheal smooth muscle. A portion of rat trachea 5 mm in length was mounted in 30 ml of Krebs solution in a muscle bath at 37 °C. The following effects of levobupivacaine were assessed: (1) the effect on tracheal smooth muscle resting tension (
n
= 6), (2) the effect on contraction caused by 10
−6
M methacholine (
n
= 6) and (3) the effect on electrically induced tracheal smooth muscle contractions (
n
= 6). Levobupivacaine caused dose-dependent relaxation in the trachealis muscle precontracted with 10
−6
M methacholine. Contraction inhibition was statistically significant when 10
−5
and 10
−4
M levobupivacaine were applied, compared with the contraction inhibition that occurred in the control groups (
p
< 0.01). A high dose of levobupivacaine also decreased the spike contraction induced by electrical field stimulation. This study indicated that high concentrations of levobupivacaine might antagonize the cholinergic receptors and inhibit parasympathetic function of the trachea.</description><subject>Anesthesiology</subject><subject>Animals</subject><subject>Bupivacaine - analogs & derivatives</subject><subject>Bupivacaine - pharmacology</subject><subject>Critical Care Medicine</subject><subject>Electric Stimulation</subject><subject>Emergency Medicine</subject><subject>Intensive</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methacholine Chloride - pharmacology</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Pain Medicine</subject><subject>Rats</subject><subject>Short Communication</subject><subject>Trachea - drug effects</subject><subject>Trachea - metabolism</subject><issn>0913-8668</issn><issn>1438-8359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EoqXwA1hQRpbA-SOOPVZV-ZAqscBsXRyHpkriYieV-PekSmFkuRvueV_pHkJuKTxQgPwxAmQCUqBZyoDJVJ2RORVcpYpn-pzMQVOeKinVjFzFuAMASSm_JDOWaZ2BhDlZrqvK2T4mvkoad_DFsK8PaLHuXOK7pI6-wd6VScA-6QParcMmia33_TZph2gbd00uKmyiuzntBfl4Wr-vXtLN2_PrarlJrQDap7kUFhUvLIdSKECBpaRCu5IzrGyW6xIlE4pjrlkmCl5hqYpK5DJ340DLF-R-6t0H_zW42Ju2jtY1DXbOD9HQnDHNqVZqROmE2uBjDK4y-1C3GL4NBXM0ZyZzZjRnjubMMXN3qh-K1pV_iV9VI8AmII6n7tMFs_ND6MaX_2n9AY4leLI</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Chang, Hung-Chi</creator><creator>Chen, Shin-Yan</creator><creator>Huang, Yu-Feng</creator><creator>Liu, Feng-Lin</creator><creator>Cherng, Yih-Giun</creator><creator>Wang, Hsing-Won</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>Effects of levobupivacaine on isolated rat tracheal smooth muscle</title><author>Chang, Hung-Chi ; Chen, Shin-Yan ; Huang, Yu-Feng ; Liu, Feng-Lin ; Cherng, Yih-Giun ; Wang, Hsing-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-764ca83bc30d480a4ad6149ed32afc579da62483a79254b3fad8bf4767e476ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anesthesiology</topic><topic>Animals</topic><topic>Bupivacaine - analogs & derivatives</topic><topic>Bupivacaine - pharmacology</topic><topic>Critical Care Medicine</topic><topic>Electric Stimulation</topic><topic>Emergency Medicine</topic><topic>Intensive</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methacholine Chloride - pharmacology</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Pain Medicine</topic><topic>Rats</topic><topic>Short Communication</topic><topic>Trachea - drug effects</topic><topic>Trachea - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Hung-Chi</creatorcontrib><creatorcontrib>Chen, Shin-Yan</creatorcontrib><creatorcontrib>Huang, Yu-Feng</creatorcontrib><creatorcontrib>Liu, Feng-Lin</creatorcontrib><creatorcontrib>Cherng, Yih-Giun</creatorcontrib><creatorcontrib>Wang, Hsing-Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Hung-Chi</au><au>Chen, Shin-Yan</au><au>Huang, Yu-Feng</au><au>Liu, Feng-Lin</au><au>Cherng, Yih-Giun</au><au>Wang, Hsing-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of levobupivacaine on isolated rat tracheal smooth muscle</atitle><jtitle>Journal of anesthesia</jtitle><stitle>J Anesth</stitle><addtitle>J Anesth</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>29</volume><issue>5</issue><spage>809</spage><epage>812</epage><pages>809-812</pages><issn>0913-8668</issn><eissn>1438-8359</eissn><abstract>Levobupivacaine has been developed as a safer alternative to bupivacaine because of its reduced systemic toxicity. However, the effect of directly delivering levobupivacaine into tracheal smooth muscle has not been adequately explored. We performed this study to determine the in vitro effects of levobupivacaine on isolated rat tracheal smooth muscle. A portion of rat trachea 5 mm in length was mounted in 30 ml of Krebs solution in a muscle bath at 37 °C. The following effects of levobupivacaine were assessed: (1) the effect on tracheal smooth muscle resting tension (
n
= 6), (2) the effect on contraction caused by 10
−6
M methacholine (
n
= 6) and (3) the effect on electrically induced tracheal smooth muscle contractions (
n
= 6). Levobupivacaine caused dose-dependent relaxation in the trachealis muscle precontracted with 10
−6
M methacholine. Contraction inhibition was statistically significant when 10
−5
and 10
−4
M levobupivacaine were applied, compared with the contraction inhibition that occurred in the control groups (
p
< 0.01). A high dose of levobupivacaine also decreased the spike contraction induced by electrical field stimulation. This study indicated that high concentrations of levobupivacaine might antagonize the cholinergic receptors and inhibit parasympathetic function of the trachea.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>25995060</pmid><doi>10.1007/s00540-015-2026-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of anesthesia, 2015-10, Vol.29 (5), p.809-812 |
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| language | eng |
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| source | Springer Link |
| subjects | Anesthesiology Animals Bupivacaine - analogs & derivatives Bupivacaine - pharmacology Critical Care Medicine Electric Stimulation Emergency Medicine Intensive Medicine Medicine & Public Health Methacholine Chloride - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Pain Medicine Rats Short Communication Trachea - drug effects Trachea - metabolism |
| title | Effects of levobupivacaine on isolated rat tracheal smooth muscle |
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