A New Antitumor Antibiotic, BE-19412A, Produced by a Streptomycete

A new antitumor substance, designated BE-19412A, was isolated from the culture broth of Streptomyces sp. A19412. The active principle was extracted from the mycelium by methanol and purified by Silica gel and Sephadex LH-20 column chromatographies. BE-19412B was prepared by methylation of BE-19412A....

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Bibliographic Details
Published in:Journal of antibiotics 1998/10/25, Vol.51(10), pp.908-914
Main Authors: TSUKAMOTO, MASAO, NAKAJIMA, SHIGERU, ARAKAWA, HIROHARU, SUGIURA, YASUYUKI, SUZUKI, HAJIME, HIRAYAMA, MIOKO, KAMIYA, SEIGO, TESHIMA, YOSHIHIRO, KONDO, HISAO, KOJIRI, KATSUHISA, SUDA, HIROYUKI
Format: Article
Language:English
Subjects:
Animals
Anthracyclines - chemistry
Anthracyclines - isolation & purification
Anthracyclines - pharmacology
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antineoplastic agents
Applied microbiology
Biological and medical sciences
Carcinoma, Ehrlich Tumor - pathology
Chemotherapic agents
Drug Screening Assays, Antitumor
Female
Fermentation
Fundamental and applied biological sciences. Psychology
General aspects
Gram-Positive Bacteria - drug effects
Humans
Isoquinolines - chemistry
Isoquinolines - isolation & purification
Isoquinolines - pharmacology
Lethal Dose 50
Magnetic Resonance Spectroscopy - methods
Mass Spectrometry
Medical sciences
Mice
Microbiology
Molecular Structure
Neoplasm Transplantation
Pharmacology. Drug treatments
Soil Microbiology
Streptomyces
Streptomyces - chemistry
Streptomyces - classification
Streptomyces - growth & development
Tumor Cells, Cultured
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Description
Summary:A new antitumor substance, designated BE-19412A, was isolated from the culture broth of Streptomyces sp. A19412. The active principle was extracted from the mycelium by methanol and purified by Silica gel and Sephadex LH-20 column chromatographies. BE-19412B was prepared by methylation of BE-19412A. BE-19412A and B exhibited cytotoxic activity against murine and human tumor cell lines. BE-19412A prolonged the survival of CDF1 mice bearing i.p. implanted Ehrlich carcinoma cells.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.908