Noninvasive investigation of exocrine pancreatic function: Feasibility of cine dynamic MRCP with a spatially selective inversion-recovery pulse

• Published in: Journal of magnetic resonance imaging 2015-11, Vol.42 (5), p.1266-1271
• Main Authors: Yasokawa, Kazuya, Ito, Katsuyoshi, Tamada, Tsutomu, Yamamoto, Akira, Hayashida, Minoru, Tanimoto, Daigo, Higaki, Atsushi, Noda, Yasufumi, Kido, Ayumu
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cholangiopancreatography, Magnetic Resonance - methods; Chronic Disease; chronic pancreatitis; cine dynamic MRCP; Feasibility Studies; Female; Humans; Image Processing, Computer-Assisted - methods; Magnetic resonance imaging; Male; Middle Aged; MR imaging; pancreas; Pancreas - physiopathology; pancreatic exocrine function; Pancreatitis - physiopathology; Reproducibility of Results
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.24906

Purpose To investigate the feasibility of noncontrast‐enhanced cine dynamic magnetic resonance cholangiopancreatography (MRCP) with a spatially selective inversion‐recovery (IR) pulse for evaluating exocrine pancreatic function in comparison with the N‐benzoyl‐L‐tyrosyl‐p‐aminobenzoic acid (BT‐PABA) test as a pancreatic exocrine function test. Materials and Methods Twenty subjects with or without chronic pancreatitis were included. MRCP with a spatially selective IR pulse was repeated every 15 seconds for 5 minutes to acquire a total of 20 images (cine‐dynamic MRCP). The median and mean frequency of the observation (the number of times) and the moving distance (mean secretion grading scores) of pancreatic juice inflow on cine‐dynamic MRCP were compared with a BT‐PABA test. Results The urinary PABA excretion rate (%) had significant positive correlations with both the mean secretion grade (r = 0.66, P = 0.002) and frequency of secretory inflow (r = 0.62, P = 0.004) in cine dynamic MRCP. Both the mean frequency of observations of pancreatic secretory inflow (1.4 ± 1.6 times vs. 14.3 ± 4.2 times, P