Novel glass-like coatings for cardiovascular implant application: Preparation, characterization and cellular interaction

Glass coatings are of great interest for biomedical implant application due to their excellent properties. Nowadays they are used in different fields including drug delivery, for bone tissue regeneration or as implant. Nevertheless they can only be applied using high temperatures. Therefore their us...

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Bibliographic Details
Published in:Materials Science & Engineering C 2016-01, Vol.58, p.812-816
Main Authors: Kiefer, Karin, Amlung, Martin, Aktas, Oral Cenk, de Oliveira, Peter W., Abdul-Khaliq, Hashim
Format: Article
Language:English
Subjects:
Biocompatibility
Cardiology
Cell Communication - drug effects
Cell Survival - drug effects
Coated Materials, Biocompatible - pharmacology
Corrosion
Glass
Glass - chemistry
Glass-like coating
Human Umbilical Vein Endothelial Cells - cytology
Human Umbilical Vein Endothelial Cells - drug effects
Humans
Implant
Prostheses and Implants
Silicates - chemistry
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Summary:Glass coatings are of great interest for biomedical implant application due to their excellent properties. Nowadays they are used in different fields including drug delivery, for bone tissue regeneration or as implant. Nevertheless they can only be applied using high temperatures. Therefore their usage in the field of cardiovascular implant application is still restricted. Accordingly new developments in this field have been carried out to overcome this problem and to coat cardiovascular implants. Here, novel glass-like coatings have been developed and applied using sol–gel technique at moderate temperatures. The biocompatibility and selectivity have been analyzed using human endothelial cells. The obtained results clarify that the developed compositions can either promote or suppress endothelial cell growth only by altering the sintering atmosphere. A later application as thin layer on cardiovascular implants like stents is conceivable. Novel flexible glass-like coatings possess good biocompatibility and selective cellular attachment by altering the sintering conditions. [Display omitted] •Novel glass-like coatings were produced using sol–gel method.•Coatings possessed excellent properties for biological testing.•Coatings were tested for cardiovascular implant application.•Biocompatibility and selective cell growth was demonstrated.
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2015.09.063