Teicoplanin use in adult patients with haematological malignancy: Exploring relationships between dose, trough concentrations, efficacy and nephrotoxicity

Highlights • Acute myeloid leukaemia diagnosis was negatively associated with trough concentration. • Higher loading doses are needed for adequate trough concentrations early in therapy. • Suggested link between trough concentration and clinical efficacy. • Teicoplanin was well tolerated renally....

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Bibliographic Details
Published in:International journal of antimicrobial agents 2015-10, Vol.46 (4), p.406-412
Main Authors: Byrne, Catherine J, Egan, Sean, Fennell, Jérôme P, O’Byrne, Philomena, Enright, Helen, Deasy, Evelyn, Ryder, Sheila A, D’Arcy, Deirdre M, McHugh, Johnny
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - pharmacokinetics
Bacterial Infections - drug therapy
Female
Haematological malignancy
Hematologic Neoplasms - complications
Humans
Infectious Disease
Male
Middle Aged
Nephrotoxicity
Pharmacokinetics
Retrospective Studies
Teicoplanin
Teicoplanin - administration & dosage
Teicoplanin - adverse effects
Teicoplanin - pharmacokinetics
Therapeutic drug monitoring
Treatment Outcome
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Summary:Highlights • Acute myeloid leukaemia diagnosis was negatively associated with trough concentration. • Higher loading doses are needed for adequate trough concentrations early in therapy. • Suggested link between trough concentration and clinical efficacy. • Teicoplanin was well tolerated renally.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.05.019