Orthostatic hypotension is associated with decreased cerebrospinal fluid levels of chromogranin A in early stage of Parkinson disease

An association between the CSF chromogranin A (CgA) and orthostatic blood pressure changes was investigated in 20 patients in the early stage of Parkinson disease (PD). There was a positive correlation between the CSF CgA and diastolic blood pressure change, when CSF CgA levels were lower in patient...

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Bibliographic Details
Published in:Clinical autonomic research 2015-10, Vol.25 (5), p.339-342
Main Authors: Kaiserova, Michaela, Prikrylova Vranova, Hana, Galuszka, Jan, Stejskal, David, Mensikova, Katerina, Zapletalova, Jana, Mares, Jan, Kanovsky, Petr
Format: Article
Language:English
Subjects:
Biomarkers - cerebrospinal fluid
Cardiology
Chromogranin A - cerebrospinal fluid
Diabetes
Endocrinology
Female
Gastroenterology
Humans
Hypotension, Orthostatic - diagnosis
Hypotension, Orthostatic - epidemiology
Male
Medicine
Medicine & Public Health
Middle Aged
Neurology
Ophthalmology
Parkinson Disease - cerebrospinal fluid
Parkinson Disease - diagnosis
Parkinson Disease - epidemiology
Short Communication
Tilt-Table Test - methods
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Summary:An association between the CSF chromogranin A (CgA) and orthostatic blood pressure changes was investigated in 20 patients in the early stage of Parkinson disease (PD). There was a positive correlation between the CSF CgA and diastolic blood pressure change, when CSF CgA levels were lower in patients with orthostatic hypotension (OH). Decreased CSF CgA may be useful in predicting OH in the early stage of PD.
ISSN:0959-9851
1619-1560
DOI:10.1007/s10286-015-0302-1