The role of ABC transporters in ovarian cancer progression and chemoresistance

Highlights • Increased expression of ABC transporters is one cause of chemoresistance. • This review summarises the roles of all 48 ABC transporters in ovarian cancer. • Current list of chemotherapy drugs transported by ABC transporters. • Summary of ABC transporter inhibitors and studies/trials ass...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2015-11, Vol.96 (2), p.220-256
Main Authors: Ween, M.P, Armstrong, M.A, Oehler, M.K, Ricciardelli, C
Format: Article
Language:English
Subjects:
ABC transporter
ATP-Binding Cassette Transporters - metabolism
Chemoresistance
Clinical trials
Disease Progression
Drug Resistance, Multiple - physiology
Drug Resistance, Neoplasm - physiology
Female
Hematology, Oncology and Palliative Medicine
Humans
Multi-drug resistance
Ovarian cancer
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - metabolism
Prognosis
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Summary:Highlights • Increased expression of ABC transporters is one cause of chemoresistance. • This review summarises the roles of all 48 ABC transporters in ovarian cancer. • Current list of chemotherapy drugs transported by ABC transporters. • Summary of ABC transporter inhibitors and studies/trials assessing therapeutic benefit. • A better understanding of their function will lead to more effective therapies.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2015.05.012