Immunologic responses and adverse reactions to Freund's-adjuvanted porcine zona pellucida immunocontraceptives in domestic cats

A vaccine of native PZP with Freund's adjuvant has been widely used in zoo and wild ungulates, but safety in felids has not been evaluated. General health, immune response, and ovarian histology were assessed in five domestic cats vaccinated with PZP-Freund's and five cats given Freund...

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Bibliographic Details
Published in:Vaccine 2005-12, Vol.23 (48), p.5646-5654
Main Authors: Munson, L., Harrenstien, L.A., Acton, A.E., Graham, P.A., Chassy, L.M., Kirkpatrick, J.F.
Format: Article
Language:English
Subjects:
Animal euthanasia
Antigens
Applied microbiology
Biological and medical sciences
Birth control
Cats
Domestic animals
Freund's adjuvant
Fundamental and applied biological sciences. Psychology
Hematology
Histology
Hypercalcemia
Immune response
Immunization
Injection
Lymph nodes
Microbiology
Monkeys & apes
Porcine zona pellucida
Renal function
Sarcoma
Side effects
Studies
Ungulata
Ungulates
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:A vaccine of native PZP with Freund's adjuvant has been widely used in zoo and wild ungulates, but safety in felids has not been evaluated. General health, immune response, and ovarian histology were assessed in five domestic cats vaccinated with PZP-Freund's and five cats given Freund's adjuvant alone. Peak antibody titers occurred 3 weeks after the third vaccination, and no ovarian lesions were present 6 months after vaccination. Seven cats developed extensive granulomatous reactions at injection sites, lymph nodes, and multiple visceral organs including lungs and brain. Persistent hypercalcemia and compromised renal function occurred in three cats with elevated serum calcitriol of probable macrophage origin. One cat died from an injection site sarcoma. Because of these severe adverse reactions, Freund's adjuvant is contraindicated in cats, and other adjuvants for PZP vaccines should be tested in cats for adverse reactions before use.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.05.044