Liver-Derived Insulin-Like Growth Factor I (IGF-I) Is the Principal Source of IGF-I in Blood but Is Not Required for Postnatal Body Growth in Mice

The body growth of animals is regulated by growth hormone and IGF-I. The classical theory of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. We have abolished IGF-I production in the livers of mice...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1999-06, Vol.96 (12), p.7088-7092
Main Authors: Sjögren, Klara, Liu, Jun-Li, Blad, Kristina, Skrtic, Stanko, Vidal, Olle, Wallenius, Ville, LeRoith, Derek, Törnell, Jan, Olle G. P. Isaksson, Jansson, John-Olov, Ohlsson, Claes
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Animals
Biological Sciences
biosynthesis
Blood
Body Weight
deficiency
Exons
Gene expression regulation
genetics
Hepatocytes
Hormones
Human growth
Insulin
Insulin-Like Growth Factor I
Insulin-Like Growth Factor I - biosynthesis
Insulin-Like Growth Factor I - deficiency
Insulin-Like Growth Factor I - genetics
Kidneys
Knockout
Liver
Liver - metabolism
MEDICAL AND HEALTH SCIENCES
MEDICIN OCH HÄLSOVETENSKAP
Messenger RNA
metabolism
Mice
Mice, Knockout
Rodents
Secretion
Somatomedins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The body growth of animals is regulated by growth hormone and IGF-I. The classical theory of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. We have abolished IGF-I production in the livers of mice by using the Cre/IoxP recombination system. These mice demonstrated complete inactivation of the IGF-I gene in the hepatocytes. Although the liver accounts for less than 5% of body mass, the concentration of IGF-I in the serum was reduced by 75%. This finding confirms that the liver is the principal source of IGF-I in the blood. However, the reduction in serum IGF-I concentration had no discernible effect on postnatal body growth. We conclude that postnatal body growth is preserved despite complete absence of IGF-I production by the hepatocytes.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.96.12.7088