Superoxide dismutase in Cryptococcus neoformans varieties gattii, grubii, and neoformans

Some clear dissimilarities occur among the varieties of Cryptococcus neoformans but there are few studies about the differences among individual yeast antioxidant enzymes. The total superoxide dismutase (SOD) activities and the copper, zinc-depend SOD (Cu,ZnSOD) and manganese-dependent SOD (MnSOD) i...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2006-02, Vol.101 (1), p.107-109
Main Authors: Dias, ALT, Brigagao, MRPL, Colepicolo, P, Siqueira, A M, da Silva, EG, Paula, C R
Format: Article
Language:English
Subjects:
Cryptococcus neoformans
Cryptococcus neoformans - superoxide dismutase - antioxidant
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Summary:Some clear dissimilarities occur among the varieties of Cryptococcus neoformans but there are few studies about the differences among individual yeast antioxidant enzymes. The total superoxide dismutase (SOD) activities and the copper, zinc-depend SOD (Cu,ZnSOD) and manganese-dependent SOD (MnSOD) isoenzymes of five reference C. neoformans strains belonged to A, B, C, AD and D serotypes (Table I) and other nine C. neoformans isolates (Table II) were determined. There were significant differences (p < 0.01 and p < 0.05) in total SOD activity among the varietie gattii (serotype C) and the other varieties. Cu,ZnSOD showed difference (p < 0.05) between A and D serotypes. These results point out a variety and serotype-independent SOD activity in C. neoformans reference strains and the other isolates that were evaluated.
ISSN:1678-8060
0074-0276
DOI:10.1590/S0074-02762006000100021