Evaluation of the Central Activity of Hydroxydihydrocarvone

The central effects of hydroxydihydrocarvone (HC), an analogue of several monoterpenes, were evaluated in animal models. General behavior, locomotor activity, pentobarbital-induced sleeping time, pentylenetetrazol (PTZ)-induced convulsions, and acetic acid-induced writhing were evaluated in mice. Th...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2006, Vol.29(4), pp.811-812
Main Authors: Sousa, Damião Pergentino de, Oliveira, Fernando de Sousa, Almeida, Reinaldo Nóbrega de
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Analgesics, Opioid - pharmacology
Animals
anticonvulsant activity
Anticonvulsants - pharmacology
antinociceptive activity
carvone
Central Nervous System Agents
Convulsants
Dose-Response Relationship, Drug
essential oil
hydroxydihydrocarvone
Hypnotics and Sedatives - pharmacology
Lethal Dose 50
Male
Mice
monoterpene
Monoterpenes - pharmacology
Morphine - pharmacology
Motor Activity - drug effects
Oils, Volatile - pharmacology
Pain Measurement - drug effects
Pentobarbital - pharmacology
Pentylenetetrazole
Seizures - chemically induced
Seizures - prevention & control
Sleep - drug effects
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Summary:The central effects of hydroxydihydrocarvone (HC), an analogue of several monoterpenes, were evaluated in animal models. General behavior, locomotor activity, pentobarbital-induced sleeping time, pentylenetetrazol (PTZ)-induced convulsions, and acetic acid-induced writhing were evaluated in mice. The compound caused palpebral ptosis, decreased the response to touch, and increased sedation (general behavioral profile). HC (50—200 mg/kg) caused a significant dose-dependent decrease in the spontaneous motor activity of mice. This compound (100, 200 mg/kg) potentiated the pentobarbital sleeping time, indicating a depressant action. HC also protected the mice against PTZ-induced convulsions at 400 mg/kg. In the acetic acid-induced writhing, the antinociceptive activity of HC was demonstrated with a significant dose-dependent response at a dose range of 25—400 mg/kg. The present results provide evidence that HC has significant psychopharmacologic activity with depressant effects.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.29.811