Milk and serum concentration of ceftiofur following intramammary infusion in goats

Five dairy goats were used to determine the milk and serum concentrations along with elimination characteristics of ceftiofur following intramammary administration. One udder half of each goat was infused twice with 125 mg ceftiofur with a 24‐h interval between infusions. Milk samples were collected...

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Bibliographic Details
Published in:Journal of veterinary pharmacology and therapeutics 2015-12, Vol.38 (6), p.569-574
Main Authors: Garrett, E. F., Dirikolu, L., Grover, G. S.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Cephalosporins - administration & dosage
Cephalosporins - analysis
Cephalosporins - blood
Cephalosporins - pharmacokinetics
Drug Administration Routes - veterinary
Female
Goat Diseases - drug therapy
Goats - metabolism
Mammary Glands, Animal
Mastitis - drug therapy
Mastitis - veterinary
Microbial Sensitivity Tests - veterinary
Milk - chemistry
Staphylococcal Infections - drug therapy
Staphylococcal Infections - veterinary
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Summary:Five dairy goats were used to determine the milk and serum concentrations along with elimination characteristics of ceftiofur following intramammary administration. One udder half of each goat was infused twice with 125 mg ceftiofur with a 24‐h interval between infusions. Milk samples were collected at 1, 2, 8, and 12 h after the last infusion and then every 12 h for a total of 7 days. Blood was collected from each animal at 3, 8, 12, and 24 h after infusion and then every 24 h for 6 days. Following a washout period of 1 week, the experiment was repeated using the opposite udder half. The elimination half‐life of ceftiofur from the mammary gland was 4.7 h. The concentration of ceftiofur was greater than published MIC₉₀ values for Staphylococcus spp. bacteria for 24 h. Ceftiofur was absorbed into systemic circulation from the mammary gland. The maximum concentration was 552 ng/mL at 3 h after infusion, and the serum elimination half‐life was 10 h. Intramammary infusion of 125 mg ceftiofur every 24 h can be expected to maintain drug concentration in milk above published MIC₉₀ for Staphylococcus spp.
ISSN:0140-7783
1365-2885
DOI:10.1111/jvp.12217