Coagulopathy in Mechanical Circulatory Support: A Fine Balance

Therapeutic intervention with mechanical circulatory support has revolutionized the medical care of individuals living with advanced heart failure. Left ventricular assist devices (LVADs) have enabled patients to live longer while providing improved quality of life and functional status. However, in...

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Bibliographic Details
Published in:Current cardiology reports 2015-12, Vol.17 (12), p.114-114, Article 114
Main Authors: Rosenthal, Julie L., Starling, Randall C.
Format: Article
Language:English
Subjects:
Anticoagulants - therapeutic use
Cardiology
Device Removal - methods
Early Diagnosis
Equipment Failure
Heart Failure (MR Mehra and E Joyce
Heart Failure - therapy
Heart-Assist Devices - adverse effects
Humans
Medicine
Medicine & Public Health
Prevalence
Prosthesis-Related Infections - physiopathology
Prosthesis-Related Infections - prevention & control
Pulsatile Flow
Quality of Life
Section Editors
Thrombosis - etiology
Thrombosis - prevention & control
Topical Collection on Heart Failure
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - physiopathology
Ventricular Dysfunction, Left - therapy
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Summary:Therapeutic intervention with mechanical circulatory support has revolutionized the medical care of individuals living with advanced heart failure. Left ventricular assist devices (LVADs) have enabled patients to live longer while providing improved quality of life and functional status. However, intervention is not without risk. Over the last decade, clinicians have identified common mechanical assist device-associated complications. This appears to be multi-factorial with relation to patient variables, inherent device technology, and nuances of concurrent medical management. This review will discuss the impact of adverse hematologic complications: bleeding, pump thrombosis, and hemolysis in continuous flow LVAD patients. These obstacles continue to pose a clinical challenge with regard to both diagnosis and optimal management. Heightened awareness and understanding of heterogeneous clinical presentations is essential for preventive management and early detection with intervention.
ISSN:1523-3782
1534-3170
DOI:10.1007/s11886-015-0670-0