Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor and Ara-C exert synergistic toxicity against human AML HL-60 cells

Human granulocyte-macrophage colony-stimulating factor fused to truncated diphtheria toxin (DT388-GM-CSF) sensitized wild-type and Bcl2-overexpressing HL60 human leukemia cells to intoxication by Ara-C based on proliferation and clonogenic assays. The toxin/drug combination showed dramatic synergist...

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Bibliographic Details
Published in:Leukemia research 1999-06, Vol.23 (6), p.527-538
Main Authors: Kim, Caryn N, Bhalla, Kapil, Kreitman, Robert J, Willingham, Mark C, Hall, Philip, Tagge, Edward P, Jia, Tao, Frankel, Authur E
Format: Article
Language:English
Subjects:
Acute Disease
Antineoplastic agents
Antineoplastic Agents - therapeutic use
Ara-C
Biological and medical sciences
Cell Cycle - drug effects
Cell Division - drug effects
Combined treatments (chemotherapy of immunotherapy associated with an other treatment)
Cytarabine - therapeutic use
Diphtheria toxin
Diphtheria Toxin - chemistry
Diphtheria Toxin - therapeutic use
Drug Synergism
GMCSF receptor
Granulocyte-Macrophage Colony-Stimulating Factor - chemistry
Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use
HL-60 Cells
Humans
Leukemia, Myeloid - drug therapy
Medical sciences
Membrane Potentials - drug effects
Mitochondria - drug effects
Myeloid leukemia cells
Pharmacology. Drug treatments
Protein Synthesis Inhibitors - therapeutic use
Recombinant Fusion Proteins - therapeutic use
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Summary:Human granulocyte-macrophage colony-stimulating factor fused to truncated diphtheria toxin (DT388-GM-CSF) sensitized wild-type and Bcl2-overexpressing HL60 human leukemia cells to intoxication by Ara-C based on proliferation and clonogenic assays. The toxin/drug combination showed dramatic synergistic toxicity with combination indices of
ISSN:0145-2126
1873-5835
DOI:10.1016/S0145-2126(99)00039-9