Curacin D, aN antimitotic agent from the marine Cyanobacterium Lyngbya majuscula

Curacin D is a novel brine shrimp toxic metabolite isolated from a Virgin Islands collection of the marine cyanobacterium Lyngbya majuscula. Structure elucidation of curacin D was accomplished through multidimensional NMR, GC/MS, and comparisons with curacin A. Curacin D provides new insights into s...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 1998-12, Vol.49 (8), p.2387-2389
Main Authors: Márquez, Brian, Verdier-Pinard, Pascal, Hamel, Ernest, Gerwick, William H.
Format: Article
Language:English
Subjects:
antiproliferative
Artemia salina
biochemical pathways
Biological and medical sciences
blue–green alga
chemical composition
chemical structure
cyanobacteria
Cyanobacteria - chemistry
General pharmacology
Humans
Lyngbya
Lyngbya majuscula
Lyngbya majuscula: Oscillatoriaceae
Magnetic Resonance Spectroscopy
Marine
Mass Spectrometry
Medical sciences
mitosis
Mitosis - drug effects
Molecular Structure
nuclear magnetic resonance spectroscopy
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
secondary metabolites
spectral analysis
structure-activity relationships
Thiazoles - chemistry
Thiazoles - isolation & purification
thiazoline alkaloid
toxicity
Tumor Cells, Cultured
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Summary:Curacin D is a novel brine shrimp toxic metabolite isolated from a Virgin Islands collection of the marine cyanobacterium Lyngbya majuscula. Structure elucidation of curacin D was accomplished through multidimensional NMR, GC/MS, and comparisons with curacin A. Curacin D provides new insights into structure–activity relationships in this natural product class as well as some aspects of the likely biosynthetic pathway of the curacins.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(98)00365-3