Microbial transformation of sarsasapogenin by Fusarium lini

The fermentation of sarsasapogenin with Fusarium lini yielded two metabolites identified as 3 β-acetoxysarsasapogenin and 7 α-hydroxysarsasapogenin. The metabolites showed dose dependent spasmolytic activity in rat duodenum.

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Bibliographic Details
Published in:Phytochemistry (Oxford) 1998-12, Vol.49 (8), p.2341-2342
Main Authors: Rahman, Atta-ur, Choudhary, M.Iqbal, Asif, Fahim, Farooq, Afgan, Yaqoob, M, Dar, Ahsana
Format: Article
Language:English
Subjects:
3-acetoxysarsasapogenin
7 α-hydroxysarsasapogenin
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Fusarium lini
General pharmacology
Medical sciences
Methods. Procedures. Technologies
microbial transformation
Miscellaneous
Pharmacology. Drug treatments
sarsasapogenin
spasmolytic activity
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Description
Summary:The fermentation of sarsasapogenin with Fusarium lini yielded two metabolites identified as 3 β-acetoxysarsasapogenin and 7 α-hydroxysarsasapogenin. The metabolites showed dose dependent spasmolytic activity in rat duodenum.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(98)00403-8