Enantiomer separation of fungicidal triazolyl alcohols by normal phase HPLC on polysaccharide-based chiral stationary phases

Three fungicidal triazolyl alcohols (triadimenol, hexaconazole, and cis/trans‐1‐4‐chlorophenyl‐2‐1H‐1,2,4‐triazol‐1‐yl‐cycloheptanol) were completely separated into enantiomers by chiral HPLC using polysaccharide‐based chiral stationary phases. A better separation was achieved on cellulose and amylo...

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Bibliographic Details
Published in:Chirality (New York, N.Y.) N.Y.), 1999, Vol.11 (3), p.195-200
Main Authors: Spitzer, Torsten, Yashima, Eiji, Okamoto, Yoshio
Format: Article
Language:English
Subjects:
amylose derivatives
cellulose derivatives
chiral stationary phase
enantiomer separation
hexaconazole
HPLC
triadimenol
triazol fungicides
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Summary:Three fungicidal triazolyl alcohols (triadimenol, hexaconazole, and cis/trans‐1‐4‐chlorophenyl‐2‐1H‐1,2,4‐triazol‐1‐yl‐cycloheptanol) were completely separated into enantiomers by chiral HPLC using polysaccharide‐based chiral stationary phases. A better separation was achieved on cellulose and amylose carbamate phases compared with a cellulose ester phase. Peak shapes were almost symmetrical except for two cases, where tailing of the first eluted enantiomer and unusual symmetric peak broadening were observed. The effect of eluents on enantioseparation was also investigated. Chirality 11:195–200, 1999. © 1999 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/(SICI)1520-636X(1999)11:3<195::AID-CHIR4>3.0.CO;2-8