β-Glucuronidase-Inhibitory Activity and Hepatoprotective Effect of Ganoderma lucidum

• Published in: Biological & pharmaceutical bulletin 1999/02/15, Vol.22(2), pp.162-164
• Main Authors: KIM, Dong-Hyun, SHIM, Sang-Bum, KIM, Nam-Jae, JANG, Il-Sung
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Carbon Tetrachloride Poisoning - prevention & control; Chemical and Drug Induced Liver Injury - prevention & control; Cholestanes - chemistry; Cholestanes - isolation & purification; Cholestanes - pharmacology; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - pharmacology; G. lucidum; ganoderenic acid A; Ganoderma lucidum; General pharmacology; Glucuronidase - antagonists & inhibitors; hepatoprotective; hepatotoxicity; Liver - drug effects; Male; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Polyporaceae - chemistry; Rats; Rats, Wistar; Spectrum Analysis; β-glucuronidase
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.22.162

To prove the relationship between the fluctuation in serum β-glucuronidase level and hepatotoxicity, an inhibitor of β-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated. The ether fraction of G. lucidum, which had potent β-glucuronidase-inhibitory activity, protected against CCl4-induced liver injury. From this ether fraction, ganoderenic acid A, was isolated as the potent inhibitor of β-glucuronidase. It had a potent hepatoprotective effect against CCl4-induced liver injury. These results suggest that the β-glucuronidase seems to be closely related to liver injury, which could be prevented by β-glucuronidase inhibitors.