The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle. The checkpoint prevents mitotic cells from exiting mitosis in the presence of unattached or improperly attached chromosomes,...

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Bibliographic Details
Published in:Current biology 2015-10, Vol.25 (20), p.R1002-R1018
Main Author: Musacchio, Andrea
Format: Article
Language:English
Subjects:
Eukaryotic Cells - physiology
M Phase Cell Cycle Checkpoints
Signal Transduction
Spindle Apparatus - physiology
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Summary:The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle. The checkpoint prevents mitotic cells from exiting mitosis in the presence of unattached or improperly attached chromosomes, thus avoiding whole-chromosome gains or losses and their detrimental effects on cell physiology. Here, I review a considerable body of recent progress in the elucidation of the molecular mechanisms underlying checkpoint signaling, and identify a number of unresolved questions. This review summarizes recent progress in the elucidation of the molecular mechanisms underlying spindle assembly checkpoint signaling, and identifies a number of unresolved questions in the field.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2015.08.051