Nonchemotherapy Drug-Induced Agranulocytosis: A Review of 118 Patients Treated with Colony-Stimulating Factors

To determine the role of growth factors in nonchemotherapy drug‐induced agranulocytosis, we reviewed 118 published reports of administration of colony‐stimulating factors for the disorder. Main outcomes were total duration of neutropenia and mortality. The mean time to neutrophil recovery was 4.6 ±...

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Bibliographic Details
Published in:Pharmacotherapy 1999-03, Vol.19 (3), p.299-305
Main Authors: Beauchesne, Marie-France, Shalansky, Stephen J.
Format: Article
Language:English
Subjects:
Adult
Aged
Agranulocytosis - chemically induced
Agranulocytosis - therapy
Biological and medical sciences
Colony-Stimulating Factors - therapeutic use
Drug toxicity and drugs side effects treatment
Female
Humans
Male
Medical sciences
Middle Aged
Neutropenia
Pharmacology. Drug treatments
Survival Analysis
Toxicity: blood
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Summary:To determine the role of growth factors in nonchemotherapy drug‐induced agranulocytosis, we reviewed 118 published reports of administration of colony‐stimulating factors for the disorder. Main outcomes were total duration of neutropenia and mortality. The mean time to neutrophil recovery was 4.6 ± 3.2 days and 7.7 ± 5.1 days in patients with a granulocyte count at diagnosis of 0.1‐0.5 × 103/mm3 and less than 0.1 × 103/mm3, respectively. The mortality rate was 4.2%. Without therapy with growth factors, the mean time to neutrophil recovery after discontinuation of the offending agent was reported to be 10 ± 8 days. The mortality rate was 16% in one study. We conclude that hematopoietic growth factors may shorten the duration of neutropenia and reduce mortality in patients with severe drug‐induced agranulocytosis.
ISSN:0277-0008
1875-9114
DOI:10.1592/phco.19.4.299.30941