M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor- beta 1

Transforming growth factor- beta 1 (TGF- beta 1) is a critical cytokine for cell proliferation and differentiation. It is secreted by many cells in a latent pro-form (LTGF- beta 1) from which biologically active TGF- beta 1 is released by an in vivo mechanism that is not known. Here we show that the...

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Bibliographic Details
Published in:European journal of immunology 1999-03, Vol.29 (3), p.1004-1013
Main Authors: Godar, S, Horejsi, V, Weidle, U H, Binder, B R, Hansmann, C, Stockinger, H
Format: Article
Language:English
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Summary:Transforming growth factor- beta 1 (TGF- beta 1) is a critical cytokine for cell proliferation and differentiation. It is secreted by many cells in a latent pro-form (LTGF- beta 1) from which biologically active TGF- beta 1 is released by an in vivo mechanism that is not known. Here we show that the mannose-6-phosphate/insulin-like growth factor II-receptor (M6P/IGFII-R), which binds LTGF- beta 1, complexes with urokinase (plasminogen activator)-receptor (uPA-R) on the surface of human monocytes and directly binds plasminogen (Plg). Plasmin generated from Plg in the complex mediates release of TGF- beta 1 when M6P/IGFII-R is associated with uPA-R. Thus, this interaction of M6P/IGFII-R and uPA-R suggests a potential mechanism for the generation of TGF- beta 1 by cells.
ISSN:0014-2980
DOI:10.1002/(SICI)1521-4141(199903)29:03<1004::AID-IMMU1004>3.0.CO;2-Q