Mutations of the beta sub(2)-microglobulin gene result in a lack of HLA class I molecules on melanoma cells of two patients immunized with MAGE peptides

Mutations have been identified in the beta sub(2)-microglobulin gene of tumor cells of two metastatic melanoma patients who received immunizations with MAGE peptides. One mutation abolishes the start codon whereas the other introduces a premature stop codon. The second beta sub(2)-microglobulin alle...

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Bibliographic Details
Published in:Tissue antigens 1998-12, Vol.52 (6), p.520-529
Main Authors: Benitez, R, Godelaine, D, Lopez-Nevot, MA, Brasseur, F, Jimenez, P, Marchand, M, Oliva, M R, van Baren, N, Cabrera, T, Andry, G, Landry, C, Ruiz-Cabello, F, Boon, T, Garrido, F
Format: Article
Language:English
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Summary:Mutations have been identified in the beta sub(2)-microglobulin gene of tumor cells of two metastatic melanoma patients who received immunizations with MAGE peptides. One mutation abolishes the start codon whereas the other introduces a premature stop codon. The second beta sub(2)-microglobulin allele of both tumors appears to be lost on the basis of sequence data and loss of microsatellite heterozygosity. The lack of beta sub(2)-microglobulin gene product results in the absence of HLA class I antigens on the surface of the tumor cells. This may explain why the tumors of both patients progressed despite the immunization treatment and shows the necessity of analyzing in depth the antigen presentation capability of the tumor cells for the interpretation of clinical trials involving anti-tumor vaccination.
ISSN:0001-2815