Rare discrepancies in a driver gene alteration within histologically heterogeneous primary lung cancers

Highlights • ITH within different histological primary lung cancers is disconcordant. • Morphologically different areas within the same tumor were extracted. • Gene status of EGFR/KRAS/ALK was assessed by assays with different sensitivity. • Rare ITHs from driving genes within primary lung adenocarc...

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Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-11, Vol.90 (2), p.205-211
Main Authors: Zhong, Wen-zhao, Su, Jian, Xu, Fang-ping, Zhai, Hao-ran, Zhang, Xu-chao, Yang, Xue-ning, Chen, Zhi-yong, Chen, Zhi-hong, Li, Wei, Dong, Song, Zhou, Qing, Yang, Jin-ji, Liu, Yan-hui, Wu, Yi-long
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenocarcinoma of Lung
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
EML4-ALK
Epidermal growth factor receptor
ErbB Receptors - genetics
Female
Hematology, Oncology and Palliative Medicine
Humans
Intratumor heterogeneity
KRAS
Lung - pathology
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Middle Aged
Mutation - genetics
Oncogene Proteins, Fusion - genetics
Pulmonary/Respiratory
ras Proteins - genetics
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Summary:Highlights • ITH within different histological primary lung cancers is disconcordant. • Morphologically different areas within the same tumor were extracted. • Gene status of EGFR/KRAS/ALK was assessed by assays with different sensitivity. • Rare ITHs from driving genes within primary lung adenocarcinomas were found. • Abundance of cells harboring driving gene and detection assays result in discrepancies.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2015.09.007