Erythroferrone: the missing link in β-thalassemia?

In this issue of Blood, Kautz et al show that the ablation of the erythroid-derived factor erythroferrone (ERFE), which has been shown to be highly expressed in β-thalassemic mice, restores hepcidin levels and corrects iron overload. However, correction of hepcidin levels in those mice does not impr...

Full description

Saved in:
Bibliographic Details
Published in:Blood 2015-10, Vol.126 (17), p.1974-1975
Main Authors: Moura, Ivan C., Hermine, Olivier
Format: Article
Language:English
Subjects:
Animals
beta-Thalassemia - complications
beta-Thalassemia - pathology
Cytokines - physiology
Disease Models, Animal
Female
Hepcidins - metabolism
Iron Overload - etiology
Male
Muscle Proteins - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this issue of Blood, Kautz et al show that the ablation of the erythroid-derived factor erythroferrone (ERFE), which has been shown to be highly expressed in β-thalassemic mice, restores hepcidin levels and corrects iron overload. However, correction of hepcidin levels in those mice does not improve anemia of β-thalassemia.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2015-09-665596