Neuroimaging in Sensory Neuronopathy

ABSTRACT Sensory neuronopathies (SN) are a group of disorders characterized by primary damage to the dorsal root ganglia neurons. Clinical features include multifocal areas of hypoaesthesia, pain, dysautonomia, and sensory ataxia, which is the major source of disability. Diagnosis relies upon clinic...

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Bibliographic Details
Published in:Journal of neuroimaging 2015-09, Vol.25 (5), p.704-709
Main Authors: Casseb, Raphael Fernandes, Martinez, Alberto Rolim Muro, de Paiva, Jean Levi Ribeiro, França Junior, Marcondes Cavalcante
Format: Article
Language:English
Subjects:
Diagnosis, Differential
Diffusion Magnetic Resonance Imaging - methods
dorsal root ganglia
Ganglia, Spinal - pathology
Hereditary Sensory and Autonomic Neuropathies - pathology
Humans
Image Enhancement - methods
Medical imaging
MRI
Neuroimaging
Neuroimaging - methods
posterior cord
Sensory neuronopathy
spinal cord
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Summary:ABSTRACT Sensory neuronopathies (SN) are a group of disorders characterized by primary damage to the dorsal root ganglia neurons. Clinical features include multifocal areas of hypoaesthesia, pain, dysautonomia, and sensory ataxia, which is the major source of disability. Diagnosis relies upon clinical assessment and nerve conductions studies, but sometimes it is difficult to distinguish SN from similar conditions, such as axonal polyneuropathies and some myelopathies. In this scenario, underdiagnosis is certainly an important issue for SN patients and additional diagnostic tools are needed. MRI is able to evaluate the dorsal columns of the spinal cord and has proven useful in the workup of SN patients. Although T2 weighted hyperintensity restricted to the posterior fasciculi without contrast enhancement is the typical finding, additional abnormalities have been recently reported. The aim of this review is to gather available information on neuroimaging findings of SN, discuss their clinical correlates and the potential impact of novel MRI‐based techniques.
ISSN:1051-2284
1552-6569
DOI:10.1111/jon.12210