Is Caffeine Abstention Necessary Before Adenosine-Induced Fractional Flow Reserve Measurement?

Conflicting results have been reported in the literature concerning the effects of caffeine on FFR measurement (3,4). [...]we designed this study to determine if caffeine abstention is required before FFR measurement and if high-dose intracoronary adenosine overcomes the caffeine antagonism. [...]ca...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2015-10, Vol.66 (17), p.1943-1945
Main Authors: Matsumoto, Hidenari, MD, PhD, Ushimaru, Shunpei, MD, Matsuda, Tetsuya, MD, PhD, Shimada, Toshihiko, MD, Mikuri, Mikiko, MD, Takahashi, Haruya, PhD, Takahashi, Nobuyuki, PhD, Kawada, Teruo, PhD, Yamazaki, Taketoshi, MD, PhD
Format: Article
Language:English
Subjects:
Adenosine - antagonists & inhibitors
Caffeine - blood
Caffeine - pharmacology
Cardiology
Cardiovascular
Coronary vessels
Fractional Flow Reserve, Myocardial - drug effects
Heart attacks
Humans
Hyperemia - chemically induced
Hyperemia - genetics
Internal Medicine
Papaverine - pharmacology
Prospective Studies
Receptors, Purinergic P1 - drug effects
Vasodilator Agents - antagonists & inhibitors
Veins & arteries
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Summary:Conflicting results have been reported in the literature concerning the effects of caffeine on FFR measurement (3,4). [...]we designed this study to determine if caffeine abstention is required before FFR measurement and if high-dose intracoronary adenosine overcomes the caffeine antagonism. [...]caffeine abstention is necessary before adenosine-induced FFR measurement, regardless of the administration route.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2015.08.034