Simultaneous determination of cloramphenicol, salicylic acid and resorcinol by capillary zone electrophoresis and its application to pharmaceutical dosage forms

This study demonstrates the separation of active ingredients in acne formulations (salicylic acid, cloramphenicol and resorcinol in presence of azulene) by capillary zone electrophoresis. Factors affecting their separations were the buffer pH and concentration, applied voltage, sample preparation, a...

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Bibliographic Details
Published in:Talanta (Oxford) 2003-10, Vol.61 (2), p.233-238
Main Authors: Gomez, Marı&#x0301, a R., Olsina, Roberto A., Martı&#x0301, nez, Luis D., Silva, Marı&#x0301, a F.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Capillary zone electrophoresis
Cloramphenicol
General pharmacology
Medical sciences
Pharmaceutical quality control
Pharmacology. Drug treatments
Resorcinol monoacetate
Salicylic acid
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Summary:This study demonstrates the separation of active ingredients in acne formulations (salicylic acid, cloramphenicol and resorcinol in presence of azulene) by capillary zone electrophoresis. Factors affecting their separations were the buffer pH and concentration, applied voltage, sample preparation, and presence of additives. Optimun results were obtained with a 50 mM sodium tetraborate–50 mM sodium phosphate, pH 9.0. The carrier electrolyte gave baseline separation with good resolution, short migration times (
ISSN:0039-9140
1873-3573
DOI:10.1016/S0039-9140(03)00267-4