Effects of N -butylphthalide on the activation of Keap1/Nrf-2 signal pathway in rats after carbon monoxide poisoning

Highlights • CO poisoning induces apoptosis-associated gene expression. • CO poisoning activates Keap1-Nrf-2/NQO1 signal pathway. • NBP regulates the ratio of Bcl-2 mRNA/Bax mRNA expressions, and enhances the ability of rats against oxidative stress.

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2015-07, Vol.40 (1), p.22-29
Main Authors: Li, Qin, Cheng, Yongmei, Bi, MingJun, Lin, Hongyang, Chen, Yufei, Zou, Yong, Liu, Yuanyuan, Kang, Hai, Guo, Yunliang
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis-associated gene
Benzofurans - toxicity
Brain - metabolism
Brain - pathology
Carbon Monoxide Poisoning - metabolism
Carbon Monoxide Poisoning - pathology
CO poisoning
Emergency
Intracellular Signaling Peptides and Proteins - metabolism
Keapl
Kelch-Like ECH-Associated Protein 1
Membrane Potential, Mitochondrial
MMP
N-Butylphthalide
NF-E2-Related Factor 2 - metabolism
NQO-1
Nrf-2
Rats
Signal Transduction - drug effects
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Summary:Highlights • CO poisoning induces apoptosis-associated gene expression. • CO poisoning activates Keap1-Nrf-2/NQO1 signal pathway. • NBP regulates the ratio of Bcl-2 mRNA/Bax mRNA expressions, and enhances the ability of rats against oxidative stress.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.05.009