Host response to Borrelia afzelii in BALB/c mice tested by immunoblotting

The aim was to find if there is variability in the production of specific antibodies by BALB/c mice to certain antigens of three individual Borrelia afzelii (dead cell suspension) strains originally isolated from different sources. Analysis of the borrelian proteins immunogenicity was performed and...

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Bibliographic Details
Published in:Annals of Agricultural and Environmental Medicine 2013, Vol.20 (4), p.823-825
Main Authors: Žákovská, Alena, Rusňáková, Helena, Vostal, Karel
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Bacterial - blood
Antibody Specificity
Antigens
Antigens, Bacterial - immunology
Borrelia afzelii
Borrelia burgdorferi Group - classification
Immunization
Immunoblotting
Immunogenicity
Immunoglobulin G
Immunoglobulin M
Lyme Disease - immunology
Lyme Disease - microbiology
Male
Mice
Mice, Inbred BALB C
OspA protein
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Summary:The aim was to find if there is variability in the production of specific antibodies by BALB/c mice to certain antigens of three individual Borrelia afzelii (dead cell suspension) strains originally isolated from different sources. Analysis of the borrelian proteins immunogenicity was performed and determined to particular strains by immunoblotting. Some differences in production of specific IgM and IgG antibodies in each individual group of tested mice were found. The antigenic influence of OspA and OspC proteins appeared to be the most important for the induction of protective immune reaction. OspC was produced both in early and late infection of all individuals and OspA induced production of IgG antibodies in all groups of immunized mice.
ISSN:1232-1966
1898-2263