Tranilast reduces serum IL-6 and IL-13 and protects against thioacetamide-induced acute liver injury and hepatic encephalopathy

Highlights • Tranilast reduces lipid peroxidation and free radicals production. • Tranilast enhances host antioxidants defense mechanisms. • Tranilast decreases elevated serum ammonia, interleukins-6 and 13. • Tranilast reduces astrocytes’ swelling and vacuolization; hallmark of hepatic encephalopat...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2015-07, Vol.40 (1), p.259-267
Main Authors: Abdelaziz, Rania R, Elkashef, Wagdi F, Said, Eman
Format: Article
Language:English
Subjects:
Acute liver injury
Ammonia
Animals
Cytokines
Emergency
Hepatic encephalopathy
Hepatic Encephalopathy - prevention & control
Interleukin-13 - blood
Interleukin-6 - blood
Liver - drug effects
Liver - injuries
Male
Nitric Oxide - blood
ortho-Aminobenzoates - pharmacology
Oxidative stress
Rats
Rats, Sprague-Dawley
Thioacetamide - toxicity
Tranilast
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Summary:Highlights • Tranilast reduces lipid peroxidation and free radicals production. • Tranilast enhances host antioxidants defense mechanisms. • Tranilast decreases elevated serum ammonia, interleukins-6 and 13. • Tranilast reduces astrocytes’ swelling and vacuolization; hallmark of hepatic encephalopathy.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.06.019