IKAROS: a multifunctional regulator of the polymerase II transcription cycle

Highlights • IKAROS has a global effect on the transcription cycle. • IKAROS associates with transcription termination proteins. • A role for the NuRD complex during elongation is proposed. • We discuss the interconnection between IKAROS, NuRD, and P-TEFb.

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Bibliographic Details
Published in:Trends in genetics 2015-09, Vol.31 (9), p.500-508
Main Authors: Bottardi, Stefania, Mavoungou, Lionel, Milot, Eric
Format: Article
Language:English
Subjects:
Animals
Chromatin Assembly and Disassembly
DNA Polymerase II - physiology
Gene Expression Regulation
hematopoiesis
Humans
IKAROS
Ikaros Transcription Factor - physiology
Medical Education
NuRD
P-TEFb
transcription elongation
transcription termination
Transcription, Genetic
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Description
Summary:Highlights • IKAROS has a global effect on the transcription cycle. • IKAROS associates with transcription termination proteins. • A role for the NuRD complex during elongation is proposed. • We discuss the interconnection between IKAROS, NuRD, and P-TEFb.
ISSN:0168-9525
DOI:10.1016/j.tig.2015.05.003