Stromal cell-derived CCL2 drives neuropathic pain states through myeloid cell infiltration in injured nerve

Highlights • Chronic neuropathic pain involves many persistent local proinflammatory processes. • The chemokine CCL2 plays a major role in the development of neuropathic pain. • Upregulation of CCL2 correlates with monocyte/macrophage infiltration and pain. • Neural CCL2 predominantly drives neuro-i...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-03, Vol.45, p.198-210
Main Authors: Van Steenwinckel, Juliette, Auvynet, Constance, Sapienza, Anaïs, Reaux-Le Goazigo, Annabelle, Combadière, Christophe, Melik Parsadaniantz, Stéphane
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Bone Marrow Transplantation
CCL2
Chemokine
Chemokine CCL2 - immunology
Constriction, Pathologic
FACS
Hyperalgesia - genetics
Hyperalgesia - immunology
Irradiated bone marrow-chimeric mice
Macrophages
Macrophages - immunology
Mice
Monocytes - immunology
Myeloid Cells - immunology
Neuralgia - immunology
Neuropathic pain
Nociceptive behavior
Peripheral Nerve Injuries - immunology
Psychiatry
Rats
Sciatic Nerve - immunology
Sciatic Nerve - injuries
Up-Regulation
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Summary:Highlights • Chronic neuropathic pain involves many persistent local proinflammatory processes. • The chemokine CCL2 plays a major role in the development of neuropathic pain. • Upregulation of CCL2 correlates with monocyte/macrophage infiltration and pain. • Neural CCL2 predominantly drives neuro-immune interactions during neuropathic pain.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2014.10.016