Vitamin D status and effect of interferon- beta 1a treatment on MRI activity and serum inflammation markers in relapsing-remitting multiple sclerosis

To explore if vitamin D modulates interferon- beta 1a treatment effects in relapsing-remitting multiple sclerosis, we examined relationships between serum vitamin D and magnetic resonance imaging (MRI) activity and ten systemic inflammation markers in 88 patients, before and during treatment. Odds r...

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Published in:Journal of neuroimmunology 2015-03, Vol.280, p.21-28
Main Authors: Roesjoe, Egil, Myhr, Kjell-Morten, Loeken-Amsrud, Kristin I, Bakke, Soeren J, Beiske, Antonie G, Bjerve, Kristian S, Hovdal, Harald, Lilleas, Finn, Midgard, Rune, Pedersen, Tom, Saltyt Benth, Jurat, Torkildsen, Oeivind, Wergeland, Stig, Michelsen, Annika E, Aukrust, Pal, Ueland, Thor, Holmoey, Trygve
Format: Article
Language:English
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Summary:To explore if vitamin D modulates interferon- beta 1a treatment effects in relapsing-remitting multiple sclerosis, we examined relationships between serum vitamin D and magnetic resonance imaging (MRI) activity and ten systemic inflammation markers in 88 patients, before and during treatment. Odds ratios for all MRI parameters were negatively associated with vitamin D levels before therapy, but converged to equally low values irrespective of vitamin D status during treatment. During therapy, similar alterations of MRI activity and inflammation markers were found across patients categorized by mean vitamin D values. This suggests that vitamin D status has no major influence on interferon- beta 1a treatment effects.
ISSN:0165-5728
DOI:10.1016/j.jneuroim.2015.02.001