Mesenchymal stem cells engrafted in a fibrin scaffold stimulate Schwann cell reactivity and axonal regeneration following sciatic nerve tubulization

Highlights • Mesenchymal stem cells (MSC) engrafting improves peripheral nerve regeneration. • MSC enhance Schwann cell response following nerve tubulization. • MSC therapy improves axonal density and enhances myelination.

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Bibliographic Details
Published in:Brain research bulletin 2015-03, Vol.112, p.14-24
Main Authors: Cartarozzi, Luciana P, Spejo, Aline B, Ferreira, Rui S, Barraviera, Benedito, Duek, Eliana, Carvalho, Juliana L, Góes, Alfredo M, Oliveira, Alexandre L.R
Format: Article
Language:English
Subjects:
Animals
Axons - pathology
Axons - physiology
Brain-Derived Neurotrophic Factor - metabolism
Cell Survival - physiology
Disease Models, Animal
Female
Fibrin
Green Fluorescent Proteins - genetics
Green Fluorescent Proteins - metabolism
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal stem cells
Mesenchymal Stromal Cells - pathology
Mesenchymal Stromal Cells - physiology
Motor Activity - physiology
Motor function recovery
Myelin Sheath - pathology
Myelin Sheath - physiology
Myelination
Nerve Regeneration - physiology
Neurology
Polyesters
Rats, Inbred Lew
Rats, Transgenic
Receptors, Nerve Growth Factor - metabolism
Recovery of Function - physiology
Schwann cell activation
Schwann Cells - pathology
Schwann Cells - physiology
Sciatic Nerve - injuries
Sciatic Nerve - pathology
Sciatic Nerve - physiopathology
Tissue Scaffolds
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Description
Summary:Highlights • Mesenchymal stem cells (MSC) engrafting improves peripheral nerve regeneration. • MSC enhance Schwann cell response following nerve tubulization. • MSC therapy improves axonal density and enhances myelination.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2015.01.005