Pregnant women infected with pandemic influenza A(H1N1)pdm09 virus showed differential immune response correlated with disease severity

• Published in: Journal of clinical virology 2015-03, Vol.64, p.52-58
• Main Authors: Periolo, N, Avaro, M, Czech, A, Russo, M, Benedetti, E, Pontoriero, A, Campos, A, Peralta, L. Martinez, Baumeister, E
• Format: Article
• Language: English
• Subjects: A(H1N1)pdm09; Adult; Allergy and Immunology; Chemokines; Chemokines - genetics; Chemokines - immunology; Chemokines - isolation & purification; Cytokines; Cytokines - genetics; Cytokines - immunology; Cytokines - isolation & purification; Female; Gene Expression Profiling; Humans; Infectious Disease; Influenza A Virus, H1N1 Subtype - immunology; Influenza virus; Influenza, Human - immunology; Influenza, Human - mortality; Influenza, Human - virology; Interferon-beta - genetics; Interferon-beta - immunology; Interleukin-6 - genetics; Interleukin-6 - immunology; Interleukin-8 - genetics; Interleukin-8 - immunology; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - mortality; Pregnant women; Retrospective Studies; Severity of Illness Index; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - immunology; Tumor Necrosis Factor-alpha - genetics
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/j.jcv.2015.01.009

Highlights • The expression of the M gene was the same in all groups of pregnant women. • No differences were observed in MCP-1, RANTES and IP-10 expression in all groups. • Increased expression of IL-8 and TGF-α in infected pregnant women. • IL-6 showed higher expression in pregnant women who died. • IFN-β and TGF-β expression were lower in those pregnant women who died.