Vaccine development for protecting swine against influenza virus

Influenza virus infects a wide variety of species including humans, pigs, horses, sea mammals and birds. Weight loss caused by influenza infection and/or co-infection with other infectious agents results in significant financial loss in swine herds. The emergence of pandemic H1N1 (A/CA/04/2009/H1N1)...

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Bibliographic Details
Published in:Animal health research reviews 2012-12, Vol.13 (2), p.181-195
Main Authors: Chen, Qi, Madson, Darin, Miller, Cathy L., Harris, D.L. Hank
Format: Article
Language:English
Subjects:
Animals
Genetic structure
Health risks
Horses
Immunization
Influenza A Virus, H1N1 Subtype - immunology
Influenza A Virus, H3N2 Subtype - immunology
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza virus
Livestock
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - prevention & control
Orthomyxoviridae Infections - veterinary
Orthomyxoviridae Infections - virology
Pandemics
Pandemics - prevention & control
Pandemics - veterinary
Public health
Swine
Swine Diseases - immunology
Swine Diseases - prevention & control
Swine Diseases - virology
Vaccination - veterinary
Vaccines
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Summary:Influenza virus infects a wide variety of species including humans, pigs, horses, sea mammals and birds. Weight loss caused by influenza infection and/or co-infection with other infectious agents results in significant financial loss in swine herds. The emergence of pandemic H1N1 (A/CA/04/2009/H1N1) and H3N2 variant (H3N2v) viruses, which cause disease in both humans and livestock constitutes a concerning public health threat. Influenza virus contains eight single-stranded, negative-sense RNA genome segments. This genetic structure allows the virus to evolve rapidly by antigenic drift and shift. Antigen-specific antibodies induced by current vaccines provide limited cross protection to heterologous challenge. In pigs, this presents a major obstacle for vaccine development. Different strategies are under development to produce vaccines that provide better cross-protection for swine. Moreover, overriding interfering maternal antibodies is another goal for influenza vaccines in order to permit effective immunization of piglets at an early age. Herein, we present a review of influenza virus infection in swine, including a discussion of current vaccine approaches and techniques used for novel vaccine development.
ISSN:1466-2523
1475-2654
DOI:10.1017/S1466252312000175