Sex differences in the early life correlates of natural antibody concentrations

Innate-like B1a lymphocytes arise from long-lived progenitors produced exclusively by fetal stem cells. Any insults coinciding with this early lymphopoietic wave could have a permanent impact on the B1a population and its unique protein products, the natural antibodies (NAb). We investigated early l...

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Bibliographic Details
Published in:Journal of developmental origins of health and disease 2015-12, Vol.6 (6), p.501-511
Main Authors: Palmer, A. C., Schulze, K. J., Khatry, S. K., De Luca, L. M., West, K. P.
Format: Article
Language:English
Subjects:
Antibodies - blood
B-Lymphocytes - physiology
Child
Child Development
Cross-Sectional Studies
Epigenetics
Female
Humans
Immunity, Humoral
Immunoglobulins
Infant
Lupus
Male
Nepal - epidemiology
Nutrition
Nutritional Status
Original Article
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Prenatal Nutritional Physiological Phenomena
Sex Factors
Womens health
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Summary:Innate-like B1a lymphocytes arise from long-lived progenitors produced exclusively by fetal stem cells. Any insults coinciding with this early lymphopoietic wave could have a permanent impact on the B1a population and its unique protein products, the natural antibodies (NAb). We investigated early life nutritional influences on NAb concentrations of pre-adolescent children (n=290) in rural Nepal for whom we had extensive information on exposures from pregnancy and early infancy. Infant size and growth were strongly associated with NAb concentrations at 9–13 years of age among males (e.g., for neonatal weight: βBOYS=0.43; P
ISSN:2040-1744
2040-1752
DOI:10.1017/S2040174415001373