Leukocyte-derived koebnerisin (S100A15) and psoriasin (S100A7) are systemic mediators of inflammation in psoriasis

Highlights • Leukocytes are a novel source of koebnerisin (S100A15) and psoriasin (S100A7). • Koebnerisin and psoriasin are induced in leukocytes of patients with psoriasis. • Koebnerisin but not psoriasin regulation marks PASI improvement by UVB therapy. • Koebnerisin and psoriasin act as ‘alarmins...

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Bibliographic Details
Published in:Journal of dermatological science 2015-09, Vol.79 (3), p.214-221
Main Authors: Batycka-Baran, Aleksandra, Hattinger, Eva, Zwicker, Stephanie, Summer, Burkhard, Zack Howard, O.M, Thomas, Peter, Szepietowski, Jacek C, Ruzicka, Thomas, Prinz, Jörg C, Wolf, Ronald
Format: Article
Language:English
Subjects:
Adult
Aged
Cytokines - blood
Cytokines - genetics
Dermatology
Female
Humans
Inflammation - blood
Interleukin-1beta - blood
Interleukin-1beta - genetics
Interleukin-6 - blood
Interleukin-6 - genetics
Interleukin-8 - blood
Interleukin-8 - genetics
Koebnerisin
Leukocytes
Leukocytes, Mononuclear - metabolism
Male
Middle Aged
Psoriasin
Psoriasis
Psoriasis - blood
Psoriasis - genetics
Psoriasis - radiotherapy
RNA - blood
S100
S100 Calcium Binding Protein A7
S100 Proteins - blood
S100 Proteins - genetics
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - genetics
Ultraviolet Therapy
UVB
Young Adult
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Summary:Highlights • Leukocytes are a novel source of koebnerisin (S100A15) and psoriasin (S100A7). • Koebnerisin and psoriasin are induced in leukocytes of patients with psoriasis. • Koebnerisin but not psoriasin regulation marks PASI improvement by UVB therapy. • Koebnerisin and psoriasin act as ‘alarmins’ on leukocytes to produce proinflammatory cytokines. • Koebnerisin and psoriasin are multifunctional mediators of inflammation.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2015.05.007