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Leukocyte-derived koebnerisin (S100A15) and psoriasin (S100A7) are systemic mediators of inflammation in psoriasis
Highlights • Leukocytes are a novel source of koebnerisin (S100A15) and psoriasin (S100A7). • Koebnerisin and psoriasin are induced in leukocytes of patients with psoriasis. • Koebnerisin but not psoriasin regulation marks PASI improvement by UVB therapy. • Koebnerisin and psoriasin act as ‘alarmins...
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| Published in: | Journal of dermatological science 2015-09, Vol.79 (3), p.214-221 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c517t-557c7514f2673d6342b604bb6958e7791b2b7b063c5f37893df339258e6c94253 |
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| cites | cdi_FETCH-LOGICAL-c517t-557c7514f2673d6342b604bb6958e7791b2b7b063c5f37893df339258e6c94253 |
| container_end_page | 221 |
| container_issue | 3 |
| container_start_page | 214 |
| container_title | Journal of dermatological science |
| container_volume | 79 |
| creator | Batycka-Baran, Aleksandra Hattinger, Eva Zwicker, Stephanie Summer, Burkhard Zack Howard, O.M Thomas, Peter Szepietowski, Jacek C Ruzicka, Thomas Prinz, Jörg C Wolf, Ronald |
| description | Highlights • Leukocytes are a novel source of koebnerisin (S100A15) and psoriasin (S100A7). • Koebnerisin and psoriasin are induced in leukocytes of patients with psoriasis. • Koebnerisin but not psoriasin regulation marks PASI improvement by UVB therapy. • Koebnerisin and psoriasin act as ‘alarmins’ on leukocytes to produce proinflammatory cytokines. • Koebnerisin and psoriasin are multifunctional mediators of inflammation. |
| doi_str_mv | 10.1016/j.jdermsci.2015.05.007 |
| format | article |
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| fulltext | fulltext |
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| ispartof | Journal of dermatological science, 2015-09, Vol.79 (3), p.214-221 |
| issn | 0923-1811 1873-569X |
| language | eng |
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| source | Elsevier |
| subjects | Adult Aged Cytokines - blood Cytokines - genetics Dermatology Female Humans Inflammation - blood Interleukin-1beta - blood Interleukin-1beta - genetics Interleukin-6 - blood Interleukin-6 - genetics Interleukin-8 - blood Interleukin-8 - genetics Koebnerisin Leukocytes Leukocytes, Mononuclear - metabolism Male Middle Aged Psoriasin Psoriasis Psoriasis - blood Psoriasis - genetics Psoriasis - radiotherapy RNA - blood S100 S100 Calcium Binding Protein A7 S100 Proteins - blood S100 Proteins - genetics Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - genetics Ultraviolet Therapy UVB Young Adult |
| title | Leukocyte-derived koebnerisin (S100A15) and psoriasin (S100A7) are systemic mediators of inflammation in psoriasis |
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