Mechanisms of anorexia–cachexia syndrome and rational for treatment with selective ghrelin receptor agonist

Highlights • Cancer cachexia is a multi-organ, multifactorial and often irreversible syndrome. • Treatment options for treating cancer cachexia are limited. • Nutritional counselling may be beneficial in delaying cachexia. • Anamorelin is a first-in-class, orally active ghrelin receptor agonist....

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Bibliographic Details
Published in:Cancer treatment reviews 2015-11, Vol.41 (9), p.793-797
Main Authors: Esposito, Angela, Criscitiello, Carmen, Gelao, Lucia, Pravettoni, Gabriella, Locatelli, Marzia, Minchella, Ida, Di Leo, Maria, Liuzzi, Rita, Milani, Alessandra, Massaro, Mariangela, Curigliano, Giuseppe
Format: Article
Language:English
Subjects:
Anamorelin
Animals
Anorexia - drug therapy
Anorexia - etiology
Anorexia - metabolism
Cachexia - drug therapy
Cachexia - etiology
Cachexia - metabolism
Cancer cachexia
Ghrelin receptor
Hematology, Oncology and Palliative Medicine
Humans
Hydrazines - pharmacology
Hydrazines - therapeutic use
Neoplasms - complications
Neoplasms - metabolism
Oligopeptides - pharmacology
Oligopeptides - therapeutic use
Receptors, Ghrelin - agonists
Receptors, Ghrelin - metabolism
Syndrome
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Summary:Highlights • Cancer cachexia is a multi-organ, multifactorial and often irreversible syndrome. • Treatment options for treating cancer cachexia are limited. • Nutritional counselling may be beneficial in delaying cachexia. • Anamorelin is a first-in-class, orally active ghrelin receptor agonist.
ISSN:0305-7372
1532-1967
DOI:10.1016/j.ctrv.2015.09.002