An observational study of cutaneous adverse drug reactions in a teaching hospital

Background Pharmacotherapy is often impeded by adverse drug reactions (ADRs). Among these ADRs cutaneous reactions are the major class being easily identified and reported. If not noted early it has potential to develop into serious lesions. Objective To evaluate the clinical patterns of various dru...

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Bibliographic Details
Published in:International journal of clinical pharmacy 2015-12, Vol.37 (6), p.996-999
Main Authors: Chopra, Deepti, Sharma, Vibha, Kapoor, Rohan, Dwivedi, Shridhar
Format: Article
Language:English
Subjects:
Adult
Adverse Drug Reaction Reporting Systems
Anti-Bacterial Agents - adverse effects
Antibiotics
Causality
Comorbidity
Drug Eruptions - epidemiology
Drug Eruptions - pathology
Drug Monitoring
Drug therapy
Female
Hospitals, Teaching
Humans
India
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Observational studies
Parapsoriasis - pathology
Pharmacy
Polypharmacy
Short Research Report
Side effects
Skin - pathology
Studies
Teaching hospitals
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Summary:Background Pharmacotherapy is often impeded by adverse drug reactions (ADRs). Among these ADRs cutaneous reactions are the major class being easily identified and reported. If not noted early it has potential to develop into serious lesions. Objective To evaluate the clinical patterns of various drug induced cutaneous reactions. Setting A Teaching hospital in India. Methods All suspected cutaneous reactions to systemic drugs which were submitted to the ADR monitoring centre during a 6-month period (March 2014–August 2014) were analysed. Causality relationship, severity assessment and preventability assessment was also done. Results Out of 134 cutaneous ADRs, 56 % occurred in females, majority of cases were found in the age group of 41–50 years. The most common type of ADR was maculopapular rash (46.3 %) and majorly implicated drug class was antibiotics (51.3 %). Most (72.3 %) were mild. Polypharmacy and multiple comorbid conditions were important predisposing factors. Over half of the cases (58 %) were not preventable. Conclusion Cutaneous adverse reaction patterns and their causes vary as the result of changing use of drugs. In India, antibiotics are responsible for the majority of the cutaneous adverse drug reactions, and maculopapular rash is the side effect that is most reported.
ISSN:2210-7703
2210-7711
DOI:10.1007/s11096-015-0161-9