Topical administration of isoflavones for treatment of vaginal symptoms in postmenopausal women: A systematic review of randomised controlled trials

Current systematic review evaluated the efficacy of topical isoflavones to relieve vaginal symptoms in menopausal women. MEDLINE (1966 to January 2014), Scopus (1990 to January 2014), and the Cochrane Central Register of Controlled Trials (The Cochrane Library issue 1, 2013) were searched using keyw...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2015-11, Vol.35 (8), p.783-787
Main Authors: Ghazanfarpour, M., Latifnejad Roudsari, R., Treglia, G., Sadeghi, R.
Format: Article
Language:English
Subjects:
Atrophy - drug therapy
Clinical trials
Dyspareunia - drug therapy
Female
Humans
Isoflavone
Isoflavones - administration & dosage
Maturation
Menopause
Phytochemicals
Postmenopause
Randomized Controlled Trials as Topic
Systematic review
topical
Urogenital system
Vagina - drug effects
Vagina - pathology
Vaginal Diseases - drug therapy
vaginal symptoms
Women
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Summary:Current systematic review evaluated the efficacy of topical isoflavones to relieve vaginal symptoms in menopausal women. MEDLINE (1966 to January 2014), Scopus (1990 to January 2014), and the Cochrane Central Register of Controlled Trials (The Cochrane Library issue 1, 2013) were searched using keywords 'isoflavone and vagina'. Relevant studies were reviewed by two independent reviewers. Only randomised controlled trials (RCTs) were included in the systematic review. Out of 115 potentially relevant publications, four studies met the inclusion criteria. Topical isoflavones showed beneficial effects on dyspareunia, vaginal dryness and maturation value. Based on only one trial, the result of conjugated equine oestrogen cream (0.3 mg/day) was similar to use of isoflavone vaginal gel and superior to that of placebo gel. However, drawing any definite conclusion was difficult because of the limited number of RCTs, the small sample sizes, weak methodology and considerable heterogeneity of the included studies.
ISSN:0144-3615
1364-6893
DOI:10.3109/01443615.2015.1011104