New international reference values for spirometry: implications for clinical issues using a comparative analysis of a paediatric population

The new lung function reference values of the global lung initiative (GLI) are recommended by most health societies. The aim of this study was to analyze FEV1- and FEV1/FVC-values from a German and Austrian patient group applying old and new reference values. A total of 215 Caucasian children (aged...

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Bibliographic Details
Published in:Wiener medizinische Wochenschrift 2015-09, Vol.165 (17-18), p.361-365
Main Authors: Lex, Christiane, Korten, Insa, Hofmann, Alexander, Renner, Sabine, Szepfalusi, Zsolt, Frischer, Thomas, Zacharasiewicz, Angela
Format: Article
Language:ger
Subjects:
Adolescent
Asthma - diagnosis
Austria
Child
Child, Preschool
Cystic Fibrosis - diagnosis
Female
Forced Expiratory Volume
Germany
Humans
Internationality
Male
Reference Values
Spirometry - standards
Statistics as Topic
Vital Capacity
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Summary:The new lung function reference values of the global lung initiative (GLI) are recommended by most health societies. The aim of this study was to analyze FEV1- and FEV1/FVC-values from a German and Austrian patient group applying old and new reference values. A total of 215 Caucasian children (aged 5-17 years) were included. FEV1-values were significantly lower applying GLI reference values compared to Zapletal values (median 96.9 % pred. (87.3-105.2) versus 100.6 % pred. (quartile 91.5-111.4), p = 0.000), the median difference was 4.9 % (range -12.9 to 27.5) % pred. Differences correlated significantly with age and FEV1 in % predicted (Zapletal), p = 0.000 17/70 (24 %) patients with cystic fibrosis had FEV1-values
ISSN:1563-258X
DOI:10.1007/s10354-015-0387-0