The effect of tremor onset on middle cerebellar peduncle of Parkinson's disease

Abstract The majority of studies of Parkinson's disease (PD) focused on basal ganglia initially; however, accumulating evidence suggests cerebellar involvement in pathophysiology. We aimed to investigate the effects of tremor onset on middle cerebellar peduncle (MCP) width of PD patients and of...

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Bibliographic Details
Published in:Journal of the neurological sciences 2015-11, Vol.358 (1), p.172-177
Main Authors: Sako, Wataru, Murakami, Nagahisa, Miyazaki, Yoshimichi, Abe, Takashi, Harada, Masafumi, Izumi, Yuishin, Kaji, Ryuji
Format: Article
Language:English
Subjects:
Aged
Cerebellum
Diagnosis, Differential
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Middle cerebellar peduncle
Middle Cerebellar Peduncle - pathology
Multiple system atrophy
Multiple System Atrophy - pathology
Neurology
Organ Size
Parkinson Disease - pathology
Parkinson's disease
Tremor
Tremor - pathology
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Summary:Abstract The majority of studies of Parkinson's disease (PD) focused on basal ganglia initially; however, accumulating evidence suggests cerebellar involvement in pathophysiology. We aimed to investigate the effects of tremor onset on middle cerebellar peduncle (MCP) width of PD patients and of disease duration on differential diagnosis. We measured MCP width of 81 PD, 34 multiple system atrophy (MSA) and 16 normal controls, using MRI. A meta-analysis was performed including two previous and the present studies. We carried out correlation analysis between disease duration and MCP width separately in subgroup of PD with or without tremor onset. Receiver operating characteristic curves were analyzed. Our meta-analysis indicated that MCP width was significantly smaller in MSA relative to PD with homogeneous studies. There was significant correlation between disease duration and MCP width in PD without tremor onset. In contrast, there was no correlation observed in PD with tremor onset. Subclassification according to disease duration showed improved area under curve of PD vs. MSA with predominant parkinsonian features. MCP width could be a valuable tool for differential diagnosis. Our finding suggested that MCP was impaired in advanced stage of PD without tremor onset as part of the abnormality of the cerebellar system.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2015.08.1531