Menstrual Patterns and Treatment of Heavy Menstrual Bleeding in Adolescents with Bleeding Disorders

• Published in: Journal of pediatric & adolescent gynecology 2015-12, Vol.28 (6), p.499-501
• Main Authors: Dowlut-McElroy, Tazim, MD, Williams, Karen B., PhD, Carpenter, Shannon L., MD, MS, Strickland, Julie L., MD, MPH
• Format: Article
• Language: English
• Subjects: Adolescent; Bleeding disorder; Blood Coagulation Disorders - complications; Child; Female; Heavy menstrual bleeding; Hormones - therapeutic use; Humans; Menarche; Menorrhagia - drug therapy; Menorrhagia - epidemiology; Menorrhagia - etiology; Menorrhagia - physiopathology; Menstrual patterns; Menstruation - physiology; Obstetrics and Gynecology; Pediatrics; Prevalence; Retrospective Studies; von Willebrand Diseases - complications; von Willebrand Diseases - physiopathology; Young Adult
• ISSN: 1083-3188; 1873-4332
• DOI: 10.1016/j.jpag.2015.03.001

Abstract Study Objective To characterize menstrual bleeding patterns and treatment of heavy menstrual bleeding in adolescents with bleeding disorders. Design, Setting, and Participants We conducted a retrospective review of female patients aged nine to 21 years with known bleeding disorders who attended a pediatric gynecology, hematology, and comprehensive hematology/gynecology clinic at a children's hospital in a metropolitan area. Main Outcome Measures Prevalence of heavy menstrual bleeding at menarche, prolonged menses, and irregular menses among girls with bleeding disorders and patterns of initial and subsequent treatment for heavy menstrual bleeding in girls with bleeding disorders. Results Of 115 participants aged nine to 21 years with known bleeding disorders, 102 were included in the final analysis. Of the 69 postmenarcheal girls, almost half (32/69, 46.4%) noted heavy menstrual bleeding at menarche. Girls with von Willebrand disease were more likely to have menses lasting longer than seven days. Only 28% of girls had discussed a treatment plan for heavy menstrual bleeding before menarche. Hormonal therapy was most commonly used as initial treatment of heavy menstrual bleeding. Half (53%) of the girls failed initial treatment. Combination (hormonal and non-hormonal therapy) was more frequently used for subsequent treatment. Conclusions Adolescents with bleeding disorders are at risk of heavy bleeding at and after menarche. Consultation with a pediatric gynecologist and/or hematologist prior to menarche may be helpful to outline abnormal patterns of menstrual bleeding and to discuss options of treatment in the event of heavy menstrual bleeding.