Safety and efficacy of low-dose pre-phase before conventional-dose chemotherapy for ulcerative gastric diffuse large B-cell lymphoma

Potentially fatal chemotherapy (CT)-related gastrorrhagia and gastric perforation in patients with gastric lymphoma present difficult problems to doctors. We retrospectively analyzed 54 patients with ulcerative gastric diffuse large B-cell lymphoma (G-DLBCL) to compare the safety and efficacy of low...

Full description

Saved in:
Bibliographic Details
Published in:Leukemia & lymphoma 2015-01, Vol.56 (9), p.2613-2618
Main Authors: Cui, Yingying, Li, Xin, Sun, Zhenchang, Leng, Changsen, Young, Ken, Wu, Xiaolong, Zhang, Lei, Fu, Xiaorui, Li, Ling, Zhang, Xudong, Chang, Yu, Nan, Feifei, Li, Zhaoming, Yan, Jiaqin, Zhou, Zhiyuan, Zhang, Mingzhi, Li, Wencai, Wang, Guannan, Zhang, Dandan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cyclophosphamide - administration & dosage
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Leukopenia - chemically induced
Lymphoma, Large B-Cell, Diffuse - drug therapy
Male
Middle Aged
Neutropenia - chemically induced
Remission Induction
Retrospective Studies
Stomach Neoplasms - drug therapy
Stomach Ulcer - drug therapy
Treatment Outcome
Vincristine - administration & dosage
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Potentially fatal chemotherapy (CT)-related gastrorrhagia and gastric perforation in patients with gastric lymphoma present difficult problems to doctors. We retrospectively analyzed 54 patients with ulcerative gastric diffuse large B-cell lymphoma (G-DLBCL) to compare the safety and efficacy of low-dose pre-phase CT before 4-6 cycles of conventional-dose CT (n = 28) with 4-6 cycles of conventional-dose CT (n = 26) between October 2005 and August 2014. Patients who received low-dose pre-phase before conventional-dose CT showed a lower gastrorrhagia or gastric perforation rate (0% vs. 15.4%, p = 0.047) and higher complete response (CR) rate (78.6% vs. 46.2%, p = 0.023) and 5-year progression-free survival (PFS) rate (63% vs. 31%, p = 0.021) than patients who received conventional-dose CT alone. Our study suggests that low-dose pre-phase therapy before conventional-dose CT provides a safe and effective method for ulcerative G-DLBCL.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428194.2015.1014366