Experimental gingivitis, bacteremia and systemic biomarkers: a randomized clinical trial

Background and Objective Bacteremia and systemic inflammatory markers are associated with periodontal and systemic diseases and may be linking mechanisms between these conditions. We hypothesized that in the development of gingival inflammation, systemic markers of inflammation and bacteremia would...

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Bibliographic Details
Published in:Journal of periodontal research 2015-12, Vol.50 (6), p.864-869
Main Authors: Kinane, D. F., Zhang, P., Benakanakere, M., Singleton, J., Biesbrock, A., Nonnenmacher, C., He, T.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
bacteremia
Bacteremia - diagnosis
Bacteremia - pathology
Biomarkers - blood
Cytokines - blood
Dentistry
experimental gingivitis
Female
Gingivitis - complications
Gingivitis - pathology
Humans
Male
Middle Aged
periodontal disease
systemic inflammation
Young Adult
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Summary:Background and Objective Bacteremia and systemic inflammatory markers are associated with periodontal and systemic diseases and may be linking mechanisms between these conditions. We hypothesized that in the development of gingival inflammation, systemic markers of inflammation and bacteremia would increase. Material and Methods To study the effect of bacteremia on systemic inflammatory markers, we recruited 80 subjects to participate in an experimental gingivitis study. Subjects were stratified based on gender, smoking and the number of bleeding sites and then randomized to one of two groups: control group (n = 40) or experimental gingivitis group (n = 40). Subjects in the control group conducted an oral hygiene regimen: brushing twice daily with a regular sodium fluoride cavity protection dentifrice and a standard manual toothbrush, flossing twice daily, and mouth rinsing with an anti‐cavity fluoride rinse once daily. The experimental group stopped brushing and flossing, and used only the fluoride anti‐cavity mouth rinse for 21 d. Results Seventy‐nine of 80 subjects were evaluable. One subject in the control group was excluded from the results due to antibiotic use during the study. Our data showed the experimental gingivitis group exhibited a significant (p 
ISSN:0022-3484
1600-0765
DOI:10.1111/jre.12280